Unexplained infertility refers to an unremarkable infertility evaluation. In other words, semen parameters were within normal limits, at least one fallopian tube is patent, the uterine cavity is normal, and menstrual cycles are regular with evidence of regular ovulation patterns. Unfortunately, a large proportion of infertile couples suffer from unexplained infertility, affecting up to 30% of couples. A normal evaluation does not indicate that there is no pathology, it simply means that available conventional testing failed to identify the cause of infertility. Most common causes of infertility in these cases are related to poor egg or sperm quality, failed fertilization, poor embryo development or defective implantation, most of which there are still no diagnostic tests.