An endometrial biopsy is done to evaluate the development of the lining of the uterus (endometrium) in relationship to ovulation. Routinely performed 7-10 days after a positive LH surge test, this test determines if the lining of the uterus is developing at the expected rate. Because a catheter is inserted into the uterus and a sample of the uterine lining is obtained, it is extremely important that you are not pregnant: this procedure has a 5% chance of disrupting an early pregnancy. It for this reason that you have been advised to avoid or have only protected intercourse during this cycle.
To help minimize the discomfort associated with the procedure, we suggest you take two Aleve (440-550mg) or three to four Motrin/Advil/Nuprin (ibuprofen 600-800mg) one hour before the biopsy. Just prior to the biopsy, a topical anesthetic may be applied to the cervix followed by cleansing with an iodine-based solution. If you are allergic to novocaine, betadine, iodine, or shellfish, please notify the doctor prior to the procedure. Once the anesthetic has had time to become effective, an instrument is placed on the cervix to hold it in place while a small plastic tube (catheter) is inserted through the cervical canal and into the uterus. It is normal to experience moderate to severe menstrual-like cramps when the catheter enters the uterus and while the biopsy is being taken, but this usually takes no more than 10-15 seconds.
Once the catheter is removed, the cramping resolves quickly. If the adequate tissue has been obtained, the procedure is complete. We advise you to avoid intercourse for two days after the procedure and call us if you experience any excessive or prolonged bleeding, temperature in excess of 100.6 degrees, pulse rate greater than 100 or excessive or prolonged pain.